Disulfiram

Indications & formulation #

Selected alcohol-dependence treatment with informed participation. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

After at least 12 hours abstinence, label initiation is up to 500 mg/day for 1–2 weeks; usual maintenance 250 mg/day, range 125–500 mg/day.

Contraindications & important cautions #

Never administer covertly or during intoxication. Avoid metronidazole, severe myocardial disease/coronary occlusion and psychosis.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Alcohol reaction, hepatotoxicity and neuropathy.

Interactions #

Review metronidazole, warfarin, phenytoin and hidden alcohol.

Monitoring #

Monitor liver symptoms/tests, understanding, consent and adherence.

Special populations #

Assess hepatic disease and interactions; baseline and follow-up liver tests are important. Pregnancy requires individual review.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

Alcohol reactions remain possible for up to 14 days after stopping. Explain hidden alcohol sources and urgent symptoms.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.