Lamotrigine

Indications & formulation #

Maintenance treatment of bipolar I disorder in adults; not acute mania treatment. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

Use the label’s bipolar titration table selected by valproate and enzyme-inducer exposure. A single universal starting schedule is inappropriate; estrogen-containing products also change exposure.

Contraindications & important cautions #

Serious rash risk rises with excessive starting doses or rapid escalation. Rash and systemic symptoms require prompt assessment.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Rash, including rare serious reactions, requires explicit counseling and assessment.

Interactions #

Valproate, enzyme inducers and estrogen-containing products affect exposure. Interruption can change restarting requirements.

Monitoring #

Follow the exact interaction-specific titration/restart schedule; assess rash and the bipolar or epilepsy indication separately.

Special populations #

Hepatic impairment requires reductions; renal impairment may affect maintenance dosing. Pregnancy and contraceptive changes require exposure review.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

After more than five half-lives off treatment, reassess initial titration. Do not routinely restart after a lamotrigine-associated rash.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.